1,6-二磷酸果糖对大鼠肝脏一氧化氮合酶体外活性的影响
Effects of fructose-1,6-diphosphate on the activity of rat liver nitric oxide synthase in vitro.
作者信息
Mihas A A, Maliakkal R J, Mihas T A, Kanji V K, Markov A K
机构信息
Veterans Affairs Medical Center, University of Mississippi School of Medicine, Jackson 39216, USA.
出版信息
Pharmacology. 1997 Jan;54(1):43-8. doi: 10.1159/000139468.
Fructose-1,6-diphosphate (FDP) was found to cause significant stimulation of nitric oxide synthase (NOS) in rat liver homogenates in vitro. This effect was more pronounced for the inducible isoform than its constitutive counterpart. Furthermore, FDP restored rat liver inducible NOS levels following their depletion by carbon tetrachloride (CCl4). This finding may have further practical implications in hepatoprotection from various noxious chemical and biological agents.
在体外实验中发现，果糖-1,6-二磷酸（FDP）能显著刺激大鼠肝脏匀浆中的一氧化氮合酶（NOS）。这种作用对诱导型同工酶的影响比对组成型同工酶更为明显。此外，在用四氯化碳（CCl4）耗尽大鼠肝脏诱导型NOS水平后，FDP能使其恢复。这一发现可能对保护肝脏免受各种有害化学和生物制剂的损伤具有进一步的实际意义。
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