Schmidt-Wilcke H A, Wolfert W, Grundmann E
Z Gastroenterol. 1977 Aug;15(8):504-11.
A case report is given on two patients receiving halothane anesthesia while beeing treated with isoniacid, ethambutol and rifampicin. Following halothane anesthesia, both patients developed a severe liver disease with encephalopathy grade III. We observed a moderate increase of bilirubin and SGOT and a more severe increase of serum ammonia. Histologically, both patients had alterations compatible with drug hepatitis. Within 14 days remission occurred spontaneously. The two case reports do not fit with typical isoniacid hepatitis or typical halothane hepatitis. The possibility of combined drug toxicity on liver during halothane and isocianid treatment is discussed.
本文报告了两例在接受异烟肼、乙胺丁醇和利福平治疗期间接受氟烷麻醉的患者。氟烷麻醉后，两名患者均出现严重肝病并伴有III级脑病。我们观察到胆红素和谷草转氨酶中度升高，血清氨升高更为严重。组织学上，两名患者均有符合药物性肝炎的改变。14天内病情自发缓解。这两例病例报告不符合典型的异烟肼肝炎或典型的氟烷肝炎。本文讨论了氟烷和异烟肼治疗期间联合药物对肝脏产生毒性的可能性。
