Frydman J, Höhfeld J
Department of Biological Sciences, Stanford University, CA 94305-5020, USA.
Trends Biochem Sci. 1997 Mar;22(3):87-92. doi: 10.1016/s0968-0004(97)01005-0.
Recent findings emphasize that different molecular chaperones cooperate during intracellular protein biogenesis. Mechanistic aspects of chaperone cooperation are now emerging from studies on the regulation of certain signal transduction pathways mediated by Hsc70 and Hsp90 in the eukaryotic cytosol. Efficient cooperation appears to be achieved through a defined regulation of Hsc70 activity by the chaperone cofactors Hip and Hop.
最近的研究结果强调，不同的分子伴侣在细胞内蛋白质生物合成过程中相互协作。目前，关于真核细胞胞质溶胶中由Hsc70和Hsp90介导的某些信号转导途径的调控研究，正在揭示伴侣蛋白协作的机制。通过伴侣蛋白辅因子Hip和Hop对Hsc70活性进行特定调控，似乎能够实现高效协作。
