Dhami S, Rumbles G, MacRobert A J, Phillips D
Department of Chemistry, Imperial College of Science, Technology & Medicine, London, UK.
Photochem Photobiol. 1997 Jan;65(1):85-90. doi: 10.1111/j.1751-1097.1997.tb01881.x.
The photophysical properties of cis-disulfonated aluminum phthalocyanine (AlPcS2) in unilamellar vesicles (liposomes) of DL-alpha-dipalmitoyl-phosphatidylcholine have been measured. Both the fluorescence and triplet quantum yields decreased with increasing sensitizer concentration. The time-resolved fluorescence decays, analyzed by both the sum of exponentials and decay time distribution analyses, are compared with those reported for AlPcS2 in leukemic K562 cells. Information on the photodynamic transport and localization mechanism has been obtained by drawing correlations between the two systems, indicating active transport of the phthalocyanine into tumor cells involving lysosomal accumulation.
已测量了顺式二磺化铝酞菁（AlPcS2）在DL-α-二棕榈酰磷脂酰胆碱单层囊泡（脂质体）中的光物理性质。荧光量子产率和三重态量子产率均随敏化剂浓度的增加而降低。通过指数之和分析和衰减时间分布分析对时间分辨荧光衰减进行了分析，并与白血病K562细胞中AlPcS2的相关报道进行了比较。通过绘制两个系统之间的相关性，获得了有关光动力转运和定位机制的信息，表明酞菁向肿瘤细胞的主动转运涉及溶酶体积累。
