Papageorgiou A, Iakovidou Z, Mourelatos D, Mioglou E, Boutis L, Kotsis A, Kovala-Demertzi D, Domopoulou A, West D X, Dermetzis M A
Laboratory of Experimental Chemotherapy Theagenion Anticancer Institute Thessaloniki, Greece.
Anticancer Res. 1997 Jan-Feb;17(1A):247-51.
The effect of novel Pd(II) complexes with derivatives of 2-acetyl-pyridinethisemicarbazone, N4-ethyl (HAc4Et) and 3-hexamethyleneiminylthiosemicarbazone (HAchexim), on Sister Chromatid Exchange (SCE) rates and human lymphocyte proliferation kinetics was studied. Also, the effect of Pd(II) complexes on DNA synthesis of P388 and L1210 cell cultures and against Leukemia P388 was investigated. Among these compounds, the compound Bis(3-hexamethyleneiminyl-2-acetylpyridine-thisemicarbazonato++ +) palladium (II) was found to be distinctly effective against Leukemia P388, in inhibiting incorporation of 3H-thymidine into DNA and in inducing SCEs and cell division delays.
研究了新型钯（II）与2-乙酰基吡啶硫代半卡巴腙衍生物N4-乙基（HAc4Et）和3-六亚甲基亚氨基硫代半卡巴腙（HAchexim）形成的配合物对姐妹染色单体交换（SCE）率和人淋巴细胞增殖动力学的影响。此外，还研究了钯（II）配合物对P388和L1210细胞培养物DNA合成的影响以及对白血病P388的作用。在这些化合物中，发现双（3-六亚甲基亚氨基-2-乙酰基吡啶-硫代半卡巴腙基++ +）钯（II）对白血病P388具有明显的抑制作用，可抑制3H-胸腺嘧啶核苷掺入DNA，并诱导SCE和细胞分裂延迟。
