Lakovidou Z, Papageorgiou A, Demertzis M A, Mioglou E, Mourelatos D, Kotsis A, Yadav P N, Kovala-Demertzi D
Laboratory of Medicinal Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Greece.
Anticancer Drugs. 2001 Jan;12(1):65-70. doi: 10.1097/00001813-200101000-00009.
The effect of three novel complexes of Pt(II) and three complexes of Pd(II) with 2-acetylpyridine thiosemicarbazone (HAcTsc) on sister chromatid exchange (SCE) rates and human lymphocyte proliferation kinetics on a molar basis was studied. Also, the effect of Pt(II) and Pd(II) complexes against leukemia P388 was investigated. Among these compounds, the most effective in inducing antitumor and cytogenetic effects were the complexes [Pt(AcTsc)2] x H2O and [Pd(AcTsc)2] while the rest, i.e. (HAcTsc), [Pt(AcTsc)Cl], [Pt(HAcTsc)2]Cl2 x 2H2O, [Pd(AcTsc)Cl] and [Pd(HAcTsc)2]Cl2, displayed marginal cytogenetic and antitumor effects.
研究了三种新型铂（II）配合物和三种钯（II）与2-乙酰基吡啶硫代半卡巴腙（HAcTsc）形成的配合物对姐妹染色单体交换（SCE）率和人淋巴细胞增殖动力学的摩尔效应。此外，还研究了铂（II）和钯（II）配合物对白血病P388的作用。在这些化合物中，诱导抗肿瘤和细胞遗传学效应最有效的是配合物[Pt(AcTsc)2]·H2O和[Pd(AcTsc)2]，而其余的，即（HAcTsc）、[Pt(AcTsc)Cl]、[Pt(HAcTsc)2]Cl2·2H2O、[Pd(AcTsc)Cl]和[Pd(HAcTsc)2]Cl2，显示出微弱的细胞遗传学和抗肿瘤效应。
