Boll I T, Domeyer C, Bührer C
Neukölln Hospital, Berlin Free University, Germany.
Acta Haematol. 1997;97(3):144-52. doi: 10.1159/000203672.
Microcinematographic documentation of mitoses, amitoses, endomitoses, or cytoplasmic fusion shortly after completion of mitoses was done in bone marrow specimens of patients with quantitative platelet disorders and controls. In patients with platelet disorders, most mitoses with cell duplication occurred in large promegakaryocytes after 4-fold nuclear and cytoplasmic enhancement. Normal specimens showed polyploidization happening in small megakaryoblasts, while mitoses with cell duplication were seen only after cultivation in freeze-thawed sera of patients with platelet disorders. Frequently, lymphocytes were observed to contact megakaryoblastic cells undergoing mitoses, amitoses and endomitoses and to enter the cytoplasm of megakaryocytes (emperipolesis), leaving it again after several hours.
对血小板数量异常患者及对照者的骨髓标本进行显微电影摄影记录，观察有丝分裂、无丝分裂、核内有丝分裂或有丝分裂完成后不久的细胞质融合情况。在血小板异常患者中，大多数细胞复制的有丝分裂发生在四倍体核和细胞质增强后的大型早幼巨核细胞中。正常标本显示多倍体化发生在小型原巨核细胞中，而细胞复制的有丝分裂仅在血小板异常患者的冻融血清中培养后才能看到。经常观察到淋巴细胞与正在进行有丝分裂、无丝分裂和核内有丝分裂的原巨核细胞接触，并进入巨核细胞的细胞质（血细胞渗出），数小时后再次离开。
