结直肠癌患者血清和组织中的唾液酸水平。

Sialic acid levels in serum and tissue from colorectal cancer patients.

作者信息

Feijoo C, Páez de la Cadena M, Rodríguez-Berrocal F J, Martínez-Zorzano V S

机构信息

Department of Fundamental Biology, University of Vigo, Spain.

出版信息

Cancer Lett. 1997 Jan 30;112(2):155-60. doi: 10.1016/s0304-3835(96)04564-8.

DOI:10.1016/s0304-3835(96)04564-8

PMID:9066722

Abstract

Sialic acid levels were determined in serum and in both normal and tumour-derived tissues from 30 patients with colorectal cancer. Total sialic acid (TSA), bound sialic acid (BSA),TSA normalised to total protein (TSA/TP) and BSA normalised to total protein (BSA/TP) were significantly higher (P < 0.0001) in sera from patients than in normal subjects. We found a trend of increasing serum sialic acid levels (TSA/TP and BSA/TP) as the malignancy became more severe (i.e. Dukes' stages A to C). Comparison of sialic acid levels between normal and tumour-derived colorectal tissues indicated no statistically significant differences in TSA, BSA or FSA (free sialic acid) levels between both tissues; however, TSA/TP and BSA/TP values were significantly decreased (P < 0.05) in the tumoral tissue. In this study, the possible relation between serum and tumour sialic acid levels in colorectal cancer patients was investigated. Our results showed that in these patients there was no correlation between serum BSA and tumour BSA levels.

摘要

测定了30例结直肠癌患者血清以及正常和肿瘤来源组织中的唾液酸水平。患者血清中的总唾液酸（TSA）、结合唾液酸（BSA）、总蛋白标准化的TSA（TSA/TP）和总蛋白标准化的BSA（BSA/TP）显著高于正常受试者（P < 0.0001）。我们发现随着恶性程度加重（即杜克分期从A到C），血清唾液酸水平（TSA/TP和BSA/TP）有升高趋势。正常和肿瘤来源的结直肠组织之间唾液酸水平的比较表明，两种组织之间的TSA、BSA或游离唾液酸（FSA）水平无统计学显著差异；然而，肿瘤组织中的TSA/TP和BSA/TP值显著降低（P < 0.05）。在本研究中，调查了结直肠癌患者血清和肿瘤唾液酸水平之间的可能关系。我们的结果表明，在这些患者中，血清BSA和肿瘤BSA水平之间无相关性。