Verazin G, Riley W M, Gregory J, Tautu C, Prorok J J, Alhadeff J A
Department of Surgery, Lehigh Valley Hospital Center, Allentown, Pennsylvania.
Dis Colon Rectum. 1990 Feb;33(2):139-42. doi: 10.1007/BF02055544.
Total sialic acid (TSA), total protein (TP), TSA normalized to total TP (TSA/TP), and carcinoembryonic antigen levels were determined in 146 consecutive colorectal patients. These results were compared with results from 73 people with nonmalignant gastrointestinal disease, and with results from 96 normal controls. All malignancies were staged according to the Astler-Coller modification of Dukes' classification for colorectal cancer. All blood samples were drawn before surgical therapy. The TSA/TP ratio for colorectal cancer was 13.4 (mg/gm) in contrast to 12.1 (mg/gm) for pathologic controls, and 9.7 (mg/gm) for normal controls. Student's t test showed a P value less than 0.001 for normal controls and a P value less than 0.001 for pathologic controls. The TSA/TP also showed statistical significance in Dukes A, B2, C, and D subgroups when compared with normal controls. There were only four patients with stage C1 carcinoma, thus statistical analysis would be questionable. In contrast, carcinoembryonic antigen levels showed no significant elevations until Dukes C2 tumors were encountered. These preliminary findings suggest that TSA/TP ratio may detect colorectal cancer patients with less tumor burden and be more beneficial as a tumor marker than CEA for monitoring patients with colorectal cancer.
对146例连续的结直肠癌患者测定了总唾液酸（TSA）、总蛋白（TP）、TSA与总TP的比值（TSA/TP）以及癌胚抗原水平。将这些结果与73例非恶性胃肠道疾病患者以及96例正常对照者的结果进行比较。所有恶性肿瘤均根据结直肠癌Dukes分类的Astler-Coller改良法进行分期。所有血样均在手术治疗前采集。结直肠癌的TSA/TP比值为13.4（mg/gm），而病理对照为12.1（mg/gm），正常对照为9.7（mg/gm）。Student t检验显示，与正常对照相比P值小于0.001，与病理对照相比P值也小于0.001。与正常对照相比，TSA/TP在Dukes A、B2、C和D亚组中也具有统计学意义。仅有4例C1期癌患者，因此统计学分析可能存在疑问。相比之下，直到遇到Dukes C2期肿瘤时癌胚抗原水平才出现显著升高。这些初步发现表明，TSA/TP比值可能检测到肿瘤负荷较小的结直肠癌患者，并且作为一种肿瘤标志物，在监测结直肠癌患者方面可能比CEA更具优势。
