Primka E J, Taylor J S
Cleveland Clinic Foundation, Department of Dermatology, OH, USA.
Am J Contact Dermat. 1997 Mar;8(1):43-6.
Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is known to be a contact sensitizer. It is used extensively in cosmetic products in low concentrations. Occupational exposure usually occurs with concentrated solutions and results in a different reaction pattern.
Three workers developed chemical burns and subsequent sensitization after exposure to concentrated solutions of MCI/MI. One patient was also occupationally sensitized to methyldibromoglutaronitrile/phenoxyethanol.
Exposure to concentrated solutions of some allergens can be severely irritating in the occupational setting and can probably induce sensitization.
甲基氯异噻唑啉酮/甲基异噻唑啉酮（MCI/MI）是一种已知的接触性致敏剂。它在化妆品中以低浓度广泛使用。职业暴露通常发生于接触浓缩溶液时，会导致不同的反应模式。
三名工人在接触MCI/MI浓缩溶液后出现化学灼伤并随后致敏。一名患者还对甲基二溴戊二腈/苯氧乙醇产生职业性致敏。
在职业环境中，接触某些过敏原的浓缩溶液可能会产生严重刺激，并可能诱发致敏。
