Kerr L R, Grimm M S, Silva W A, Weinberg J, Emerman J T
Department of Anatomy, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Cancer Res. 1997 Mar 15;57(6):1124-8.
In the present study, we demonstrate that social housing conditions significantly alter the response of the transplantable androgen-responsive Shionogi mouse mammary tumor (SC115) to chemotherapy. Mice were reared either in groups (G) or as individuals (I). Immediately following tumor cell or vehicle injection, mice were rehoused from group to individual (GI) or from individual to group (IG) conditions. A combination of Adriamycin (4 mg/kg) and cyclophosphamide (61.5 mg/kg), in a series of three i.p. injections 7 days apart, was initiated when mean tumor weights of mice within a housing condition (GI or IG) reached 1 g. Survival probability was significantly greater in mice in the IG housing condition compared to those in the GI housing condition (47% versus 19%, respectively). Additionally, the median survival time following the initiation of chemotherapy was greater for mice in the IG than for mice in the GI condition (24.5 days versus 15.0 days, respectively). These findings suggest that a psychosocial stressor, social housing condition, can significantly influence chemotherapeutic efficacy.
在本研究中，我们证明社会居住条件会显著改变可移植的雄激素反应性狮王小鼠乳腺肿瘤（SC115）对化疗的反应。小鼠被成群饲养（G组）或单独饲养（I组）。在注射肿瘤细胞或赋形剂后，立即将小鼠从群居环境转移到单独环境（GI组）或从单独环境转移到群居环境（IG组）。当某一居住条件（GI组或IG组）下小鼠的平均肿瘤重量达到1 g时，开始使用阿霉素（4 mg/kg）和环磷酰胺（61.5 mg/kg）联合进行腹腔注射，每隔7天注射一次，共注射三次。与GI组的小鼠相比，IG组小鼠的生存概率显著更高（分别为47%和19%）。此外，化疗开始后的中位生存时间，IG组小鼠比GI组小鼠更长（分别为24.5天和15.0天）。这些发现表明，一种心理社会应激源，即社会居住条件，会显著影响化疗效果。
