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通过荧光原位杂交技术，将cathelicidin家族的六个抗菌肽基因定位到牛的22号染色体22q24区域。

Six antimicrobial peptide genes of the cathelicidin family map to bovine chromosome 22q24 by fluorescence in situ hybridization.

作者信息

Castiglioni B, Scocchi M, Zanetti M, Ferretti L

机构信息

Istituto per la Difesa e la Valorizzazione del Germoplasma Animale, CNR, Milano, Italy.

出版信息

Cytogenet Cell Genet. 1996;75(4):240-2. doi: 10.1159/000134492.

DOI:10.1159/000134492
PMID:9067433
Abstract

Six phage clones containing gene members of the family of antimicrobial peptides named cathelicidins, were mapped to bovine chromosome 22q24, by means of fluorescence in situ hybridization. The mapping data suggest the clustering of cathelicidins into a CATHL@ locus, in a similar manner as for beta-defensins, another family of antimicrobial peptides, defining the locus DEFB@ mapped to 27q13-->q14.

摘要

通过荧光原位杂交技术，将六个含有名为cathelicidins的抗菌肽家族基因成员的噬菌体克隆定位到牛的22号染色体q24区域。定位数据表明，cathelicidins以类似于β-防御素（另一个抗菌肽家族）的方式聚集在一个CATHL@基因座中，β-防御素的基因座DEFB@定位在27号染色体q13→q14区域。

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引用本文的文献

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