Tonosaki K, Miwa K, Kanemura F
Department of Veterinary Physiology, Faculty of Agriculture, Gifu University, Japan. tonosaki_at_cc.dec.aedu.gifu-u.ac.jp.
Brain Res. 1997 Feb 14;748(1-2):234-6. doi: 10.1016/s0006-8993(96)01360-1.
Mouse gustatory responses to sucrose, monellin and thaumatin were examined extracellularly from the chorda tympani nerve and intracellularly from individual taste receptor cells. Although monellin and thaumatin taste intensely sweet to humans and old-world monkeys, they do not appear to elicit chorda tympani nerve responses in rats and other mammals. However, there is considerable species variation in the taste responses of mammals, including differences in taste responses of different strains of mice. In the present study with Slc:ICR mice, we show that chorda tympani and taste receptor cell response profiles, and behavioral results for monellin and thaumatin, are similar to response profiles for sucrose.
通过鼓索神经细胞外记录和单个味觉受体细胞内记录，检测了小鼠对蔗糖、莫奈林和索马甜的味觉反应。尽管莫奈林和索马甜对人类和旧世界猴来说味道极甜，但它们似乎不会在大鼠和其他哺乳动物中引发鼓索神经反应。然而，哺乳动物的味觉反应存在相当大的物种差异，包括不同品系小鼠的味觉反应差异。在本研究中，使用Slc:ICR小鼠，我们发现鼓索神经和味觉受体细胞的反应谱，以及莫奈林和索马甜的行为学结果，与蔗糖的反应谱相似。
