Rodríguez M D, Sánchez M, García H
Department of Toxicology, National Center for Scientific Research, Havana, Cuba.
Toxicol Lett. 1997 Feb 7;90(2-3):97-106. doi: 10.1016/s0378-4274(96)03844-1.
The hypocholesterolaemic drug policosanol was administered to Sprague-Dawley rats of both sexes throughout three successive generations at concentrations of 0, 5, 50 and 500 mg/kg bw/day by gavage. For each generation two litters were reared until they were at least 3 weeks old. No clinical signs which could be related to the administration of the test substance were observed in the F0, F1b and F2b parents. There were no differences among groups in the number of animals that conceived, the number of pups born live or dead, the rate of male to female pups, the number of pups that survived until weaning and the pups' body weights through the lactancy. The following test showed no treatment-related effects on F3b offspring: righting on a surface, air righting, corneal, pirmal and pain reflexes, auditory startle and visual placing. The results of the present study did not demonstrate any deleterious effects on the fertility, reproductive performance or development of rats administered policosanol at levels of up to 500 mg/kg bw/day over three successive generations.
将降胆固醇药物多廿烷醇以0、5、50和500毫克/千克体重/天的浓度通过灌胃法连续三代给予雌雄Sprague-Dawley大鼠。每一代饲养两窝直至至少3周龄。在F0、F1b和F2b代亲代中未观察到与受试物给药相关的临床症状。在受孕动物数量、出生的活仔或死仔数量、雄性与雌性仔鼠比例、存活至断奶的仔鼠数量以及哺乳期仔鼠体重方面，各实验组之间无差异。以下测试表明对F3b代后代无处理相关影响：表面翻正、空中翻正、角膜反射、初级反射和疼痛反射、听觉惊跳和视觉放置。本研究结果未表明连续三代给予大鼠高达500毫克/千克体重/天剂量的多廿烷醇会对其生育力、生殖性能或发育产生任何有害影响。
