Montravers F, Ricard M, Lumbroso J, Di Paola M, Schlumberger M, Parmentier C, Di Paola R
INSERM U66, Villejuif, France.
Clin Nucl Med. 1997 Mar;22(3):151-7. doi: 10.1097/00003072-199703000-00003.
Digital superimposition of SPECT and CT data was evaluated in a phantom and then applied to patient data. Seven patients were studied. Six patients had pheochromocytomas as evidenced by I-131 or I-123 MIBG localization and one had ovarian cancer imaged by In-111 OC125 MoAb. Anatomic or skin landmarks identified the level of each SPECT transaxial slice. Both SPECT and CT image data sets were transferred to a minicomputer connected to an image processor. Afterwards, a scaled, rotated and translated realignment was performed. Data for each modality were coded in different primary colors and then superimposed. Superimposition of phantom data was checked for the absence of distortion of pinpoint and large structures. For suspected tumor sites, superimposition of the patients' slices were allowed to check for matching SPECT and CT abnormalities to localize a SPECT abnormality without a corresponding CT lesion or to distinguish SPECT abnormalities from those seen on CT. In one case, the technique failed because of very low I-131 MIBG-tumor uptake. The superimposition decreases false positives in SPECT and both false negatives or false positives in CT.
在体模中评估了单光子发射计算机断层扫描（SPECT）和计算机断层扫描（CT）数据的数字叠加，然后将其应用于患者数据。研究了7名患者。6名患者经I-131或I-123间碘苄胍（MIBG）定位证实患有嗜铬细胞瘤，1名患者经铟-111 OC125单克隆抗体成像显示患有卵巢癌。通过解剖标志或皮肤标志确定每个SPECT横断面切片的水平。SPECT和CT图像数据集均被传输到连接图像处理器的小型计算机。之后，进行了缩放、旋转和平移重新对齐。每种模态的数据用不同的原色编码，然后叠加。检查体模数据的叠加情况，看是否存在针尖状和大结构的变形。对于疑似肿瘤部位，允许叠加患者的切片，以检查SPECT和CT异常是否匹配，从而定位无相应CT病变的SPECT异常，或区分SPECT异常与CT上所见的异常。在1例中，由于I-131 MIBG对肿瘤的摄取非常低，该技术失败。叠加减少了SPECT中的假阳性以及CT中的假阴性或假阳性。
