Meden H, Mielke S, Schauer A, Kuhn W
Department of Obstetrics and Gynecology, University of Göttingen, Germany.
In Vivo. 1997 Jan-Feb;11(1):51-4.
The c-erbB-2 encoded oncoprotein p185 is overexpressed in fetal epithelial cells, in the placenta, and in several human carcinomas. Elevated serum levels of the 105 kD extracellular part are found in cancer patients and in pregnancy. Our purpose was to examine whether there is a characteristic development of p105 serum levels in the course of normal pregnancy. Using ELISA, we measured the p105 serum concentrations in nonpregnant women, women with normal pregnancy in the 1st, 2nd, and 3rd trimester and pueperas. Compared to nonpregnant women, we found a significant decrease in p105 in the 1st and 2nd trimester, followed by a significant increase in the 3rd trimester. Post partum serum values returned to the levels found in nonpregnant women. The clinical judgment of female p105 serum values requires comparison with the normal range of random samples, and the consideration of pregnancy and the age of gestation as in vivo influencing factors.
由c-erbB-2编码的癌蛋白p185在胎儿上皮细胞、胎盘以及几种人类癌症中过度表达。癌症患者和孕妇血清中105kD细胞外部分的水平升高。我们的目的是研究在正常妊娠过程中p105血清水平是否有特征性变化。我们采用酶联免疫吸附测定法（ELISA），测量了未怀孕女性、妊娠1期、2期和3期的正常孕妇以及产后女性血清中p105的浓度。与未怀孕女性相比，我们发现妊娠1期和2期p105显著降低，随后在妊娠3期显著升高。产后血清值恢复到未怀孕女性的水平。对女性p105血清值的临床判断需要与随机样本的正常范围进行比较，并将妊娠和妊娠年龄作为体内影响因素加以考虑。
