Parks J H, Coward M, Coe F L
Department of Medicine, University of Chicago, Illinois, USA.
Kidney Int. 1997 Mar;51(3):894-900. doi: 10.1038/ki.1997.126.
Supersaturation (SS) with respect to calcium oxalate monohydrate (COM), brushite (Br) and uric acid (UA), obtained in three 24-hour pretreatment urine samples from patients with stone disease were compared to the mineral composition of stones passed by the same patients to determine whether sparse urine SS measurements accurately reflect the long-term average SS values in the kidney and final urine. Among males and females elevation of SS above same sex normals corresponded to composition. As well, treatments that reduced stone rates also reduced these SS values. The degree of calcium phosphate (CaP) admixture was accurately matched by shifting magnitudes of COM and Br SS. As well, increasing CaP content was associated with falling urine citrate and rising urine pH, suggesting renal tubular acidosis. We conclude that sparse urine SS measurements accurately track stone admixtures, and are a reliable index of average renal and urine SS.
将结石病患者的三份24小时预处理尿液样本中获得的相对于一水草酸钙（COM）、透钙磷石（Br）和尿酸（UA）的过饱和度（SS），与同一患者排出的结石矿物质成分进行比较，以确定少量尿液SS测量值是否能准确反映肾脏和最终尿液中的长期平均SS值。在男性和女性中，SS高于同性正常水平与结石成分相对应。此外，降低结石发生率的治疗方法也降低了这些SS值。COM和Br SS的变化幅度准确匹配了磷酸钙（CaP）的混合程度。此外，CaP含量增加与尿枸橼酸盐降低和尿pH值升高相关，提示肾小管酸中毒。我们得出结论，少量尿液SS测量值能准确追踪结石混合物，是肾脏和尿液平均SS的可靠指标。
