Schlamp C L, Williams D S
School of Optometry, Indiana University, Bloomington 47405, USA.
Exp Eye Res. 1996 Dec;63(6):613-9. doi: 10.1006/exer.1996.0155.
Brain myosin V is a member of a class of unconventional myosins. Using antibodies against brain myosin V, its distribution in the rat retina has been examined. It was detected in the inner and outer plexiform layers, in the somas of cells forming the inner nuclear layer, and in the ganglion cell layers. Faint labeling was also detected in the inner segments of the photoreceptor cells. In semithin retinal sections and isolated rod photoreceptor cells, a bright punctate labeling pattern was observed in the outer plexiform layer, corresponding to the rod photoreceptor synapses. The results found suggest that a major role of myosin V in the outer retina is in these synapses.
脑肌球蛋白V是一类非传统肌球蛋白的成员。利用抗脑肌球蛋白V的抗体，研究了其在大鼠视网膜中的分布。在内、外网状层、构成内核层的细胞体以及神经节细胞层中均检测到了它。在光感受器细胞的内段也检测到了微弱的标记。在半薄视网膜切片和分离的视杆光感受器细胞中，在外网状层观察到明亮的点状标记模式，对应于视杆光感受器突触。研究结果表明，肌球蛋白V在外视网膜中的主要作用存在于这些突触中。
