Lindblad L E
Acta Physiol Scand. 1977 Sep;101(1):43-9. doi: 10.1111/j.1748-1716.1977.tb05981.x.
In 30 healthy subjects aged 20--48 years the hemodynamic response to carotid sinus stimulation (neck suction -40 mmHg) was studied. Heart rate, arterial pressure and cardiac output (dye dilution technique) were measured. In order to evaluate the effect of age on carotid sinus function the material was subdivided into two arbitrary subgroups, aged up to 30 years (n = 15) respectively 30 years and above (n = 15). Carotid sinus stimulation induced a significantly greater reduction in mean arterial pressure in the younger group compared to the older group. The heart rate reduction was, on the average, slightly greater in the younger group though the difference was not significant. In both groups a significant decrease in cardiac output contributed to the demonstrated reduction in mean arterial pressure. As the decrease in cardiac output was, on the average, slightly smaller in the younger group, the results indicate that the greater blood pressure response in the younger group was due to a greater reduction in peripheral vascular resistance. This is further supported by the finding of a significant correlation between changes in total peripheral vascular resistance, elicited by carotid sinus stimulation and age.
在30名年龄在20至48岁的健康受试者中，研究了对颈动脉窦刺激（颈部负压-40 mmHg）的血流动力学反应。测量了心率、动脉压和心输出量（染料稀释技术）。为了评估年龄对颈动脉窦功能的影响，将研究对象任意分为两个亚组，分别为30岁及以下（n = 15）和30岁及以上（n = 15）。与老年组相比，颈动脉窦刺激在年轻组中引起的平均动脉压降低更为显著。年轻组的心率降低平均略大于老年组，尽管差异不显著。两组的心输出量均显著下降，这导致了平均动脉压的降低。由于年轻组的心输出量平均下降略小，结果表明年轻组更大的血压反应是由于外周血管阻力的更大降低。颈动脉窦刺激引起的总外周血管阻力变化与年龄之间存在显著相关性，这一发现进一步支持了上述结论。
