儿童期/青春期早期起病型和成年期起病型精神分裂症。多巴胺D3受体基因的异质性。
Childhood/early adolescence-onset and adult-onset schizophrenia. Heterogeneity at the dopamine D3 receptor gene.
作者信息
Maziade M, Martinez M, Rodrigue C, Gauthier B, Tremblay G, Fournier C, Bissonnette L, Simard C, Roy M A, Rouillard E, Mérette C
机构信息
Centre de recherche Université Laval Robert-Giffard, Beauport, Québec, Canada.
出版信息
Br J Psychiatry. 1997 Jan;170:27-30. doi: 10.1192/bjp.170.1.27.
BACKGROUND
The dopamine D3 receptor gene (DRD3) is a meaningful candidate gene because it unifies the dopamine and the limbic hypotheses for schizophrenia. We tested for an allelic association between schizophrenia and the DRD3 Mscl alleles, hypothesising heterogeneity between childhood/early adolescence-onset schizophrenia (CO-SZ) and adult-onset schizophrenia (A-SZ).
METHOD
The frequencies of the DRD3 alleles were compared between 70 DSM-III-R schizophrenics (35 CO-SZ and 35 A-SZ) and 79 controls.
RESULTS
Compared with the controls, the subsample of A-SZ, but not CO-SZ, showed an over-proportion (P = 0.025) of allele 1. The association was not found in the total sample, combining the two subsamples.
CONCLUSIONS
Consistently with former studies, our data suggest an aetiological heterogeneity between CO-SZ and A-SZ and a possible specificity of the excess of allele 1 to the familial form of schizophrenia and to schizophrenia with a better outcome.
背景
多巴胺D3受体基因（DRD3）是一个有意义的候选基因，因为它将精神分裂症的多巴胺假说和边缘系统假说统一起来。我们检测了精神分裂症与DRD3 Mscl等位基因之间的等位基因关联，假设儿童期/青春期早期起病的精神分裂症（CO-SZ）和成年期起病的精神分裂症（A-SZ）之间存在异质性。
方法
比较了70名符合《精神疾病诊断与统计手册》第三版修订版（DSM-III-R）标准的精神分裂症患者（35例CO-SZ和35例A-SZ）与79名对照者中DRD3等位基因的频率。
结果
与对照组相比，A-SZ亚组而非CO-SZ亚组的1等位基因比例过高（P = 0.025）。在将两个亚组合并的总样本中未发现这种关联。
结论
与之前的研究一致，我们的数据表明CO-SZ和A-SZ之间存在病因异质性，并且1等位基因过量可能对家族性精神分裂症形式以及预后较好的精神分裂症具有特异性。
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