Nanko S, Sasaki T, Fukuda R, Hattori M, Dai X Y, Kazamatsuri H, Kuwata S, Juji T, Gill M
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
Hum Genet. 1993 Oct;92(4):336-8. doi: 10.1007/BF01247330.
A study of the genetic association between schizophrenia and a BalI polymorphism in exon 1 of the dopamine D3 (DRD3) gene, a candidate gene for schizophrenia, was conducted. The polymorphism was examined in 91 patients whose symptoms satisfied DSM-III-R for schizophrenia and 90 controls. There were no significant differences between the groups in allele frequencies or genotype counts. Contrary to a previous report, the patients were no more likely to be homozygous than controls. Moreover, no association with the presence of illness could be demonstrated when the patients were grouped according to sex, age of onset, history of admission to psychiatric institutions or positive family history.
对精神分裂症与多巴胺D3（DRD3）基因外显子1中的BalI多态性之间的遗传关联进行了研究，DRD3基因是精神分裂症的一个候选基因。在91名症状符合DSM-III-R精神分裂症标准的患者和90名对照中检测了该多态性。两组之间的等位基因频率或基因型计数没有显著差异。与之前的一份报告相反，患者并不比对照组更易出现纯合子。此外，根据性别、发病年龄、入住精神病机构的病史或阳性家族史对患者进行分组时，未发现与患病情况存在关联。
