Mora-Ferrer C, Neumeyer C
Institut für Zoologie III, Johannes Gutenberg Universität Mainz, Germany.
Vision Res. 1996 Dec;36(24):4035-44. doi: 10.1016/s0042-6989(96)00173-3.
Reduction of wavelength discrimination ability in the 560-640 nm range, but not in the 404-540 nm range, has been demonstrated in goldfish after intravitreal injection of D1-dopamine receptor antagonists. Intravitreal injection of the dopaminergic neurotoxin 6-OH-dopamine severely reduced wavelength discrimination ability in the 540-661 nm range within 3 days. Discrimination ability could be reconstituted by the D1-agonist SKF 38393. Animals recovered from injection of 6-OH-dopamine within 14-16 days. No change of wavelength discrimination was induced by 6-OH-dopamine in the 461-540 nm range. We conclude that under photopic conditions dopamine modulates retinal mechanisms involved in red-green colour coding via D1-dopamine receptor-like binding sites.
玻璃体内注射 D1 - 多巴胺受体拮抗剂后，已证实在金鱼中，560 - 640 纳米范围内的波长辨别能力降低，但在 404 - 540 纳米范围内未降低。玻璃体内注射多巴胺能神经毒素 6 - 羟基多巴胺在 3 天内严重降低了 540 - 661 纳米范围内的波长辨别能力。辨别能力可通过 D1 - 激动剂 SKF 38393 恢复。动物在 14 - 16 天内从 6 - 羟基多巴胺注射中恢复。6 - 羟基多巴胺在 461 - 540 纳米范围内未引起波长辨别变化。我们得出结论，在明视觉条件下，多巴胺通过类似 D1 - 多巴胺受体的结合位点调节参与红绿色编码的视网膜机制。
