Kamakura S, Sasano Y, Nakamura M, Suzuki O, Ohki H, Kagayama M, Motegi K
Department of Maxillofacial Surgery I, School of Dentistry, Tohoku University, Sendai, Japan.
Arch Oral Biol. 1996 Nov;41(11):1029-38. doi: 10.1016/s0003-9969(96)00080-5.
The study was designed to investigate the process of bone formation caused by implantation of octacalcium phosphate as well as stability of the bone formed at the alveolar ridge. Synthetic octacalcium phosphate was implanted into a subperiosteal pocket in the rat mandible. Bone formation at the alveolar ridge was examined radiographically and histologically between 1 and 48 week(s) after implantation. Radiopacity of the octacalcium phosphate implant became obvious in week 2. Osteogenesis was initiated from the bone surface near the implantation site and multinucleated giant cells appeared on the implanted octacalcium phosphate in week 1. More apposition of new bone was observed on the implanted octacalcium phosphate in week 2 or later. Some implants were directly enclosed by newly formed bone and no cellular component was seen between the implant and the bone matrix. Many octacalcium phosphate implants were enclosed by bone, whereas the augmented ridge was not seen radiographically in week 24 or later. If its persistence can be improved, octacalcium phosphate could be used to augment atrophic alveolar ridges.
本研究旨在调查植入磷酸八钙后引起的骨形成过程以及牙槽嵴处形成骨的稳定性。将合成磷酸八钙植入大鼠下颌骨的骨膜下袋中。在植入后1至48周之间，通过影像学和组织学检查牙槽嵴处的骨形成情况。磷酸八钙植入物的不透射线性在第2周变得明显。成骨从植入部位附近的骨表面开始，第1周时在植入的磷酸八钙上出现多核巨细胞。在第2周或之后，在植入的磷酸八钙上观察到更多新骨的附着。一些植入物被新形成的骨直接包裹，在植入物和骨基质之间未见细胞成分。许多磷酸八钙植入物被骨包裹，而在第24周或之后影像学上未见到牙槽嵴增大。如果其持久性能够得到改善，磷酸八钙可用于增大萎缩性牙槽嵴。
