Leppik I E
University of Minnesota, MINCEP, Minneapolis 65416, USA.
Baillieres Clin Neurol. 1996 Dec;5(4):749-55.
At the present time monotherapy is preferable to polytherapy if the epilepsy can be controlled with a single drug. However, persons with intractable epilepsy may need more than one antiepileptic drug to attain the best seizure control with the fewest side-effects. Although clinical studies have not been performed to identify the best combinations, rational polytherapy would imply combining antiepileptic drugs with different mechanisms of action.
