Clark L T, Garfein O B, Dwyer E M
Am J Med. 1983 Aug;75(2):332-6. doi: 10.1016/0002-9343(83)91213-5.
The natural history of acute cardiogenic pulmonary edema was studied in a group of patients who did not have acute myocardial infarction, cardiomyopathy, or valvular heart disease. Most of these patients had coronary artery disease. Cardiac catheterization in selected patients showed depressed contractility in some with segmental abnormalities. In the group older than 70 years, this carried a 70 percent two-year mortality rate. It is important to approach patients with this syndrome vigorously, both diagnostically and therapeutically. Acute, reversible segmental ischemia may be responsible for this syndrome and may respond to measures designed to prevent recurrent ischemia.
在一组没有急性心肌梗死、心肌病或瓣膜性心脏病的患者中，对急性心源性肺水肿的自然病史进行了研究。这些患者大多数患有冠状动脉疾病。部分选定患者的心脏导管检查显示，一些患者存在节段性异常且收缩力降低。在70岁以上的患者组中，两年死亡率为70%。对患有该综合征的患者进行积极的诊断和治疗非常重要。急性、可逆性节段性缺血可能是该综合征的病因，采取预防反复缺血的措施可能会有效果。
