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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.

Gen Pharmacol. 1997 Mar;28(3):345-50. doi: 10.1016/s0306-3623(96)00169-3.

Adenosine is a normal constituent of all body fluids and its levels are raised, for example, by hypoxia and ischemia. In addition, both adenosine and ATP can be released by endothelial cells and neutrophils in response to physiologic stimulation. 2. Human neutrophil leukocytes possess multiple adenosine receptors and P2 purinoceptors. 3. ATP can increase intracellular Ca2+ levels in neutrophils, cause degranulation and enzyme release, potentiate the oxidative burst and enhance their adhesion to the endothelium. ATP is broken down to adenosine by ecto-enzymes. Via A1 receptors, adenosine can increase neutrophil chemotaxis and, via A2A receptors, it can decrease the oxidative burst, degranulation and adhesion to endothelium. 4. Adenosine and adenine nucleotides are important endogenous modulators of neutrophil functions, and drugs may exert important actions via purinoceptors on neutrophil leukocytes.

腺苷是所有体液的正常成分，其水平会因缺氧和缺血等情况而升高。此外，腺苷和三磷酸腺苷（ATP）可由内皮细胞和中性粒细胞在生理刺激下释放。2. 人类中性粒细胞具有多种腺苷受体和P2嘌呤受体。3. ATP可提高中性粒细胞内的钙离子水平，导致脱颗粒和酶释放，增强氧化爆发并增强其与内皮的黏附。ATP被外切酶分解为腺苷。通过A1受体，腺苷可增加中性粒细胞趋化性，通过A2A受体，它可减少氧化爆发、脱颗粒以及与内皮的黏附。4. 腺苷和腺嘌呤核苷酸是中性粒细胞功能的重要内源性调节剂，药物可能通过嘌呤受体对中性粒细胞发挥重要作用。

Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.

Gen Pharmacol. 1997 Mar;28(3):345-50. doi: 10.1016/s0306-3623(96)00169-3.

Adenosine is a normal constituent of all body fluids and its levels are raised, for example, by hypoxia and ischemia. In addition, both adenosine and ATP can be released by endothelial cells and neutrophils in response to physiologic stimulation. 2. Human neutrophil leukocytes possess multiple adenosine receptors and P2 purinoceptors. 3. ATP can increase intracellular Ca2+ levels in neutrophils, cause degranulation and enzyme release, potentiate the oxidative burst and enhance their adhesion to the endothelium. ATP is broken down to adenosine by ecto-enzymes. Via A1 receptors, adenosine can increase neutrophil chemotaxis and, via A2A receptors, it can decrease the oxidative burst, degranulation and adhesion to endothelium. 4. Adenosine and adenine nucleotides are important endogenous modulators of neutrophil functions, and drugs may exert important actions via purinoceptors on neutrophil leukocytes.

腺苷是所有体液的正常成分，其水平会因缺氧和缺血等情况而升高。此外，腺苷和三磷酸腺苷（ATP）可由内皮细胞和中性粒细胞在生理刺激下释放。2. 人类中性粒细胞具有多种腺苷受体和P2嘌呤受体。3. ATP可提高中性粒细胞内的钙离子水平，导致脱颗粒和酶释放，增强氧化爆发并增强其与内皮的黏附。ATP被外切酶分解为腺苷。通过A1受体，腺苷可增加中性粒细胞趋化性，通过A2A受体，它可减少氧化爆发、脱颗粒以及与内皮的黏附。4. 腺苷和腺嘌呤核苷酸是中性粒细胞功能的重要内源性调节剂，药物可能通过嘌呤受体对中性粒细胞发挥重要作用。