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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Takahashi Y, Mizuno H, Ohno H, Misawa M

Department of Pharmacology, SS Pharmaceutical Co., Chiba, Japan.

Gen Pharmacol. 1997 Mar;28(3):399-404. doi: 10.1016/s0306-3623(96)00351-5.

The biphasic reflex tracheal response (constriction followed by dilatation) occurred during bronchoconstriction induced by inhalation of ovalbumin antigen (OA) in sensitized guinea pigs. 2. The reflex tracheal constriction was largely reduced by atropine, and the dilatation was inhibited by propranolol and N omega-nitro-L-arginine methyl ester (L-NAME). The noradrenaline, adrenaline, cyclic AMP, and cyclic GMP contents in the tracheal segment were significantly higher during reflex tracheal dilatation. 3. These findings suggest that cholinergic nerves may mediate reflex tracheal constriction and that adrenergic and NOergic nerves may mediate the ensuing reflex tracheal dilatation.

在致敏豚鼠吸入卵清蛋白抗原（OA）诱导支气管收缩期间，出现双相反射性气管反应（先收缩后扩张）。2. 阿托品可大幅减轻反射性气管收缩，普萘洛尔和N-ω-硝基-L-精氨酸甲酯（L-NAME）可抑制扩张。在反射性气管扩张期间，气管段中的去甲肾上腺素、肾上腺素、环磷酸腺苷和环磷酸鸟苷含量显著升高。3. 这些发现表明，胆碱能神经可能介导反射性气管收缩，而肾上腺素能神经和一氧化氮能神经可能介导随后的反射性气管扩张。

Takahashi Y, Mizuno H, Ohno H, Misawa M

Department of Pharmacology, SS Pharmaceutical Co., Chiba, Japan.

Gen Pharmacol. 1997 Mar;28(3):399-404. doi: 10.1016/s0306-3623(96)00351-5.

The biphasic reflex tracheal response (constriction followed by dilatation) occurred during bronchoconstriction induced by inhalation of ovalbumin antigen (OA) in sensitized guinea pigs. 2. The reflex tracheal constriction was largely reduced by atropine, and the dilatation was inhibited by propranolol and N omega-nitro-L-arginine methyl ester (L-NAME). The noradrenaline, adrenaline, cyclic AMP, and cyclic GMP contents in the tracheal segment were significantly higher during reflex tracheal dilatation. 3. These findings suggest that cholinergic nerves may mediate reflex tracheal constriction and that adrenergic and NOergic nerves may mediate the ensuing reflex tracheal dilatation.

在致敏豚鼠吸入卵清蛋白抗原（OA）诱导支气管收缩期间，出现双相反射性气管反应（先收缩后扩张）。2. 阿托品可大幅减轻反射性气管收缩，普萘洛尔和N-ω-硝基-L-精氨酸甲酯（L-NAME）可抑制扩张。在反射性气管扩张期间，气管段中的去甲肾上腺素、肾上腺素、环磷酸腺苷和环磷酸鸟苷含量显著升高。3. 这些发现表明，胆碱能神经可能介导反射性气管收缩，而肾上腺素能神经和一氧化氮能神经可能介导随后的反射性气管扩张。