Raf-1调控的复杂性。
The complexity of Raf-1 regulation.
作者信息
Morrison D K, Cutler R E
机构信息
Molecular Basis of Carcinogenesis Laboratory, ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.
出版信息
Curr Opin Cell Biol. 1997 Apr;9(2):174-9. doi: 10.1016/s0955-0674(97)80060-9.
The activation of the serine/threonine kinase Raf-1 is proving to be an intricate multistep process. Recent advances in elucidating how Raf-1 becomes activated in response to signaling events have emphasized the role of phosphorylation and protein interactions in Raf-1 regulation. The picture clearly emerging is that Raf-1 activity can be regulated by multiple mechanisms.
丝氨酸/苏氨酸激酶Raf-1的激活正被证明是一个复杂的多步骤过程。在阐明Raf-1如何响应信号事件而被激活方面的最新进展强调了磷酸化和蛋白质相互作用在Raf-1调节中的作用。清晰呈现的情况是，Raf-1的活性可通过多种机制进行调节。
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