Calabrese E J
Am Ind Hyg Assoc J. 1977 Sep;38(9):443-6. doi: 10.1080/0002889778507649.
The general formula approach for the development of TLVs for novel work schedules represents a reasonable first attempt in dealing with this new industrial health problem. However, several additional factors should be considered in the derivation of novel work schedule TLVs. They include: 1. the individuals who are at increased risk with respect to the pollutant in question; 2. the possible influences of rotational changes and disrupted circadian rhythms on health status of workers adopting the proposed novel schedules; 3. the type of toxicologic response to be affected and the degree of safety margin built into the TLV; 4. the metabolic rate and fate of the substance in the individual.
为新型工作时间表制定阈限值（TLVs）的通用公式方法，是应对这一新的职业健康问题的合理首次尝试。然而，在推导新型工作时间表的阈限值时，还应考虑几个其他因素。这些因素包括：1. 就所涉污染物而言风险增加的个体；2. 轮班变化和昼夜节律紊乱对采用拟议新型时间表的工人健康状况的可能影响；3. 受影响的毒理学反应类型以及阈限值中的安全系数；4. 个体体内该物质的代谢率和归宿。
