White W L, Wieselthier J S, Hitchcock M G
Department of Pathology, North Carolina Baptist Hospital, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, USA.
Semin Cutan Med Surg. 1996 Dec;15(4):278-99. doi: 10.1016/s1085-5629(96)80042-3.
Dermatopathologists rarely greet a biopsy of panniculitis with total confidence that a specific, definitive diagnosis will be rendered. As with many other areas in dermatopathology, our understanding of the pathogenesis of many forms of panniculitis is incomplete. This article examines a subset of panniculitis primarily from a pathogenetic standpoint, with the intention of providing a differential diagnosis for those cases in which ischemic changes are seen in the subcutis. The diverse group of conditions evoked by this approach also shares the distinction of having been the focus of nosologic and causative controversy, both historically and currently. In particular, stasis-associated sclerosing panniculitis, vascular calcification-cutaneous necrosis syndrome (calciphylaxis), oxalosis, and nodular vasculitis-erythema induratum are examined in depth. Erythema nodosum and variants, other granulomatous panniculitides, and panniculitides showing cytophagocytosis are also discussed with current perspectives.
皮肤病理学家在面对脂膜炎活检时，很少能完全自信地做出特定的、明确的诊断。与皮肤病理学的许多其他领域一样，我们对多种形式脂膜炎发病机制的理解并不完整。本文主要从发病机制的角度研究脂膜炎的一个子集，旨在为皮下出现缺血性改变的病例提供鉴别诊断。通过这种方法引发的多种情况在历史上和当前都一直是疾病分类学和病因学争议的焦点。特别是，对与淤滞相关的硬化性脂膜炎、血管钙化 - 皮肤坏死综合征（钙过敏）、草酸沉着症和结节性血管炎 - 硬结性红斑进行了深入研究。还从当前角度讨论了结节性红斑及其变体、其他肉芽肿性脂膜炎以及表现为噬细胞现象的脂膜炎。
