Silber M H
Department of Neurology, Mayo Clinic Rochester, Minnesota 55905, USA.
Mayo Clin Proc. 1997 Mar;72(3):261-4. doi: 10.4065/72.3.261.
Restless legs syndrome is a common condition characterized by unpleasant limb sensations that are precipitated by rest and relieved by activity. Symptoms are worse during the evening and may result in insomnia. Most cases are idiopathic, although the condition is sometimes familial and may be associated with a range of medical illnesses, including chronic renal failure and iron deficiency anemia. Restless legs syndrome is responsive to several medications, including levodopa, dopamine agonists, benzodiazepines, opioids, and some anticonvulsants. A practical approach to management involves a stepwise plan, commencing with intermittent therapy with less potent agents for mild cases and progressing to medications with greater potency but a higher potential for side effects.
不宁腿综合征是一种常见病症，其特征为肢体出现不适感，休息时发作，活动后缓解。症状在傍晚时加重，可能导致失眠。大多数病例为特发性，不过该病症有时具有家族性，且可能与一系列内科疾病有关，包括慢性肾衰竭和缺铁性贫血。不宁腿综合征对多种药物有反应，包括左旋多巴、多巴胺激动剂、苯二氮䓬类药物、阿片类药物以及一些抗惊厥药。一种切实可行的治疗方法包括一个逐步推进的方案，对于轻症病例，先采用效力较弱的药物进行间歇性治疗，然后进展到效力更强但副作用可能性更高的药物。
