López-Jaramillo P
Unidad de Metabolismo Mineral, Facultad de Ciencias Médicas, Universidad Central e Instituto de Investigaciones para el Desarrollo de la Salud (lides), Ministerio de Salud Pública, Quito, Ecuador.
Braz J Med Biol Res. 1996 Jun;29(6):731-41.
Pregnancy-induced hypertension (PIH) remains a common cause of maternal and fetal morbidity and mortality. During the past 7 years, some progress has been made in the prevention of PIH. Specifically, clinical studies have shown that supplementation with calcium can significantly reduce the frequency of PIH, especially in populations with a low calcium intake. We have suggested that, in such a population, calcium supplementation is a safe and effective measure for reducing the incidence of PIH. Calcium supplementation reduces the risk of PIH by maintaining the serum ionized calcium level which is crucial for the production of endothelial nitric oxide, the increased generation of which maintains the vasodilatation that is characteristic of normal pregnancy. In PIH there is an impaired nitric oxide synthesis and cyclic GMP production.
妊娠高血压疾病（PIH）仍然是孕产妇和胎儿发病及死亡的常见原因。在过去7年中，PIH的预防取得了一些进展。具体而言，临床研究表明，补充钙可显著降低PIH的发生率，尤其是在钙摄入量低的人群中。我们认为，在这类人群中，补充钙是降低PIH发生率的一种安全有效的措施。补充钙通过维持血清离子钙水平来降低PIH风险，血清离子钙水平对于内皮一氧化氮的产生至关重要，内皮一氧化氮生成增加可维持正常妊娠特有的血管舒张。在PIH中，一氧化氮合成和环磷酸鸟苷生成受损。
