López-Jaramillo P, Terán E, Moncada S
Mineral Metabolism Unit, Faculty of Medicine, Central University, Quito, Ecuador.
Med Hypotheses. 1995 Jul;45(1):68-72. doi: 10.1016/0306-9877(95)90205-8.
Pregnancy-induced hypertension (PIH) remains a common cause of maternal and fetal morbidity and mortality. During the past 7 years, some progress has been made in the prevention of PIH. Specifically, clinical studies have shown that supplementation with calcium can significantly reduce the frequency of PIH, specially in populations with a low calcium intake. We have suggested that, in such a population, calcium supplementation is a safe and effective measure for reducing the frequency of PIH. Thus, the purpose of this article is to advance a hypothesis about the mechanism by which calcium supplementation reduces the risk of PIH. We propose that dietary calcium supplementation reduces the frequency of PIH by maintaining the serum ionized calcium level which is crucial for the production of endothelial nitric oxide, the increased generation of which maintains the vasodilatation that is characteristic of normal pregnancy.
妊娠高血压综合征（PIH）仍然是孕产妇和胎儿发病及死亡的常见原因。在过去7年里，PIH的预防取得了一些进展。具体而言，临床研究表明，补充钙可显著降低PIH的发生率，特别是在钙摄入量低的人群中。我们认为，在这类人群中，补充钙是降低PIH发生率的一种安全有效的措施。因此，本文的目的是提出一个关于补充钙降低PIH风险机制的假说。我们提出，膳食补充钙通过维持血清离子钙水平来降低PIH的发生率，而血清离子钙水平对于内皮一氧化氮的产生至关重要，内皮一氧化氮生成增加可维持正常妊娠所特有的血管舒张。
