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全髋关节置换术中聚乙烯髋臼部件的磨损。对128个在尸检或翻修手术中取出的部件的分析。

Wear of polyethylene acetabular components in total hip arthroplasty. An analysis of one hundred and twenty-eight components retrieved at autopsy or revision operations.

作者信息

Jasty M, Goetz D D, Bragdon C R, Lee K R, Hanson A E, Elder J R, Harris W H

机构信息

Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.

出版信息

J Bone Joint Surg Am. 1997 Mar;79(3):349-58.

PMID:9070522
Abstract

We evaluated the rates of volumetric wear and the patterns of wear of 128 acetabular components retrieved during an autopsy or a revision operation between one and twenty-one years after total hip arthroplasty. Twenty-two all-polyethylene components were retrieved at autopsy from hips that had been functioning well at the time of death (Group A). The remaining 106 components--eighty-four all-polyethylene components (Group B) and twenty-two metal-backed components (Group C)--were retrieved during revision operations. All 128 components had been inserted with cement. The mean rate of volumetric wear, determined directly with a fluid-displacement method, was thirty-five cubic millimeters per year (range, eight to 116 cubic millimeters per year) for Group A, sixty-two cubic millimeters per year (range, eight to 256 cubic millimeters per year) for Group B, and ninety-four cubic millimeters per year (range, twelve to 284 cubic millimeters per year) for Group C. Multivariate regression analysis showed a significant relationship (p < 0.05) between the size of the femoral head and the calculated mean annual rate of volumetric wear. The rate of volumetric wear was highest in association with thirty-two-millimeter femoral heads and lowest in association with twenty-two-millimeter heads; according to linear regression analysis, this represented a 7.5 per cent increase (Group A) or a 10 per cent increase (Group B) in the rate of wear for every one-millimeter increase in the size of the head. Linear regression analysis also showed a significant relationship between the duration that the implant had been in situ and the rate of wear (p < 0.05), with the rate being highest initially after the operation and decreasing with an increasing duration in situ. With the numbers available, the patient's age and gender and the side of the arthroplasty did not have a significant relationship to the annual rate of volumetric wear. Increased thickness of the polyethylene was related to a decreased rate of wear (p < 0.05) in the group of metal-backed components, which had a 25 per cent increase in the rate of wear for every one-millimeter decrease in thickness, but not in the other groups. The estimated median annual rates of wear, after adjustment of confounding variables to a hypothetical constant set of median values for the parameters (duration in situ, 132 months; diameter of the femoral head, twenty-six millimeters; and thickness of the polyethylene, eight millimeters), were significantly different among the three groups of components (p < 0.05). Histological evaluation of the worn surfaces showed the predominant mechanisms of wear to be abrasion and adhesion rather than fatigue-cracking or delamination. The highly worn areas were polished to a glassy finish on gross examination, but scanning electron microscopy showed numerous multidirectional scratches along with fine, drawn-out fibrils with a diameter of one micrometer or less oriented parallel to each other. These fibrils are the most likely source of submicrometer wear particles. Thus, wear appeared to occur mostly at the surface of the components and to be due to large-strain plastic deformation and orientation of the surface layers into fibrils that subsequently ruptured during multidirectional motion.

摘要

我们评估了128个髋臼组件的体积磨损率及磨损模式,这些组件是在全髋关节置换术后1至21年的尸检或翻修手术中取出的。22个全聚乙烯组件是从死亡时功能良好的髋关节尸检中取出的(A组)。其余106个组件——84个全聚乙烯组件(B组)和22个金属背衬组件(C组)——是在翻修手术中取出的。所有128个组件均用骨水泥固定。通过流体置换法直接测定的平均体积磨损率,A组为每年35立方毫米(范围为8至116立方毫米/年),B组为每年62立方毫米(范围为8至256立方毫米/年),C组为每年94立方毫米(范围为12至284立方毫米/年)。多变量回归分析显示股骨头大小与计算出的平均年体积磨损率之间存在显著关系(p<0.05)。体积磨损率在与32毫米股骨头相关时最高,与22毫米股骨头相关时最低;根据线性回归分析,股骨头尺寸每增加1毫米,磨损率在A组增加7.5%,在B组增加10%。线性回归分析还显示植入物在位时间与磨损率之间存在显著关系(p<0.05),磨损率在术后最初最高,随着在位时间增加而降低。就现有数据而言,患者的年龄、性别及关节置换的侧别与年体积磨损率无显著关系。在金属背衬组件组中,聚乙烯厚度增加与磨损率降低相关(p<0.05),厚度每减少1毫米,磨损率增加25%,但在其他组中并非如此。在将混杂变量调整为参数的一组假设恒定中位数(在位时间132个月;股骨头直径26毫米;聚乙烯厚度8毫米)后,三组组件的估计年磨损中位数显著不同(p<0.05)。对磨损表面的组织学评估显示,主要磨损机制是磨损和粘着,而非疲劳裂纹或分层。在大体检查中,高度磨损区域被打磨成玻璃样光洁度,但扫描电子显微镜显示有许多多方向划痕以及直径为1微米或更小、彼此平行排列的细拉伸纤维。这些纤维最可能是亚微米级磨损颗粒的来源。因此,磨损似乎主要发生在组件表面,是由于大应变塑性变形以及表面层形成纤维并在多方向运动中随后破裂所致。

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