Kiss H, Klein M, Egarter C, Graf A H, Hacker G, Hütter W, Czerwenka K, Husslein P
Department of Obstetrics and Gynecology, University of Vienna, Austria.
Hum Reprod. 1997 Feb;12(2):383-6. doi: 10.1093/humrep/12.2.383.
The degree to which the relative rise of serum human chorionic gonadotrophin (HCG) concentration was related to proliferative cell activity and the biological vitality of tubal pregnancy was investigated. Salpingectomy was performed in 15 patients diagnosed as having non-ruptured tubal pregnancy. Serum HCG was evaluated twice preoperatively, with a 48-h time interval. Proliferative cell activity was measured through the use of the cell proliferation marker 'Ki-67'. A significant correlation between the relative increase in HCG over a 48-h period, independent of the initial serum HCG value, and the biological cell activity of the trophoblast was shown. Furthermore, it became evident that cell activity was also correlated to the intracellular HCG of the trophoblast. The relative increase in serum HCG over a period of 48 h can serve as a parameter for the biological activity of the trophoblast in tubal pregnancies.
研究了血清人绒毛膜促性腺激素（HCG）浓度的相对升高与增殖细胞活性及输卵管妊娠生物活力之间的关联程度。对15例诊断为未破裂输卵管妊娠的患者进行了输卵管切除术。术前每隔48小时对血清HCG进行两次评估。通过使用细胞增殖标志物“Ki-67”来测量增殖细胞活性。结果显示，在48小时内HCG的相对增加与初始血清HCG值无关，且与滋养层的生物细胞活性之间存在显著相关性。此外，很明显细胞活性也与滋养层细胞内的HCG相关。48小时内血清HCG的相对增加可作为输卵管妊娠中滋养层生物活性的一个参数。
