Klein M, Graf A, Kiss H, Czerwenka K, Beck A, Egarter C, Husslein P
Department of Gynecology, Hanusch-Krankenhaus, Vienna, Austria.
Arch Gynecol Obstet. 1995;256(2):85-8. doi: 10.1007/BF00634713.
beta-HCG (human chorionic gonadotropin) values of over 2500 I.U./l are associated with higher failure rates for therapy with prostaglandin F2 alpha in tubal pregnancies. The purpose of our study was to ascertain if the 2500 I.U./l limit correlates with histopathology. We therefore compared the pre-operative beta-HCG-values and intraluminal and extraluminal trophoblast growth in tubal pregnancy. Purely intraluminal trophoblast was significantly more frequent in patients of group I (beta-HCG < 2500 I.U./l), while group II patients (beta-HCG > 2500 I.U./l) almost exclusively had extraluminal growth (P = 0.0045). Since the efficacy of prostaglandin F2 alpha therapy depends on intact tubal musculature the correlation of the beta-HCG threshold level with histopathologic findings may explain the high failure rate in patients with beta-HCG values above 2500 I.U./l.
β-人绒毛膜促性腺激素（β-HCG）值超过2500国际单位/升与输卵管妊娠中前列腺素F2α治疗的较高失败率相关。我们研究的目的是确定2500国际单位/升这个界限是否与组织病理学相关。因此，我们比较了输卵管妊娠患者术前的β-HCG值以及管腔内和管腔外滋养层的生长情况。在第一组患者（β-HCG＜2500国际单位/升）中，单纯管腔内滋养层明显更为常见，而第二组患者（β-HCG＞2500国际单位/升）几乎全部为管腔外生长（P = 0.0045）。由于前列腺素F2α治疗的疗效取决于完整的输卵管肌肉组织，β-HCG阈值水平与组织病理学结果之间的相关性可能解释了β-HCG值高于2500国际单位/升的患者中高失败率的原因。
