Mattei M G, Roeckel N, Olsen B R, Apte S S
Hospital d'Enfants, INSERM U406, Groupe Hospitalier de la Timone, Marseille, France.
Genomics. 1997 Feb 15;40(1):168-9. doi: 10.1006/geno.1996.4559.
The membrane-type matrix metalloproteinases (MT-MMPs) constitute a newly discovered family of four enzymes within the matrix metalloproteinase (MMP) superfamily. We have mapped the genes for MT1-MMP (MMP14), MT2-MMP (MMP15), and MT3-MMP (MMP16) using in situ hybridization to human metaphase chromosomes. In contrast to the genes for many MMPs that are clustered on chromosome 11, the genes MMP14, MMP15, and MMP16 all map to distinct chromosomes. MMP14 maps to human chromosome 14, MMP15 to human chromosome 16, and MMP16 to human chromosome 8.
膜型基质金属蛋白酶（MT-MMPs）是在基质金属蛋白酶（MMP）超家族中新发现的一个由四种酶组成的家族。我们利用原位杂交技术将MT1-MMP（MMP14）、MT2-MMP（MMP15）和MT3-MMP（MMP16）的基因定位到人类中期染色体上。与许多聚集在11号染色体上的MMP基因不同，MMP14、MMP15和MMP16基因均定位于不同的染色体上。MMP14定位于人类14号染色体，MMP15定位于人类16号染色体，MMP16定位于人类8号染色体。
