Vanni R, Marras S, Schoenmakers E F, Dal Cin P, Kazmierczak B, Senger G, Bullerdiek J, Van de Ven W J, Van den Berghe H
Institute of General Biology, University of Cagliari, Italy.
Genes Chromosomes Cancer. 1997 Mar;18(3):155-61. doi: 10.1002/(sici)1098-2264(199703)18:3<155::aid-gcc1>3.0.co;2-0.
Uterine leiomyoma cytogenetically exhibits at least six chromosomally abnormal subgroups. The largest subgroup is characterized by deletions of the long arm of chromosome 7. Few molecular and fluorescence in situ hybridization data are available that have aimed at a better definition of the lesion. Here, we report the results of a partial molecular cytogenetic characterization of two del(7q) chromosomes that were derived from cell lines established from two uterine leiomyomas with del(7)(q22q32). By using a large series of ordered 7q markers, we were able to identify the most proximal and the most distal conserved markers, which delineate the size of the deletion and which allow for a more targeted approach to the nature and function of genes that are possibly relevant for the pathogenesis of the disorder.
子宫平滑肌瘤在细胞遗传学上至少表现出六个染色体异常亚组。最大的亚组特征是7号染色体长臂缺失。旨在更好地定义该病变的分子和荧光原位杂交数据很少。在此，我们报告了两个del(7q)染色体的部分分子细胞遗传学特征结果，这两个染色体来源于从两个具有del(7)(q22q32)的子宫平滑肌瘤建立的细胞系。通过使用大量有序的7q标记，我们能够识别最近端和最远端的保守标记，这些标记描绘了缺失的大小，并允许对可能与该疾病发病机制相关的基因的性质和功能采用更有针对性的方法。
