Kinghorn B P
Department of Animal Science, University of New England, Armidale, Australia.
Genetics. 1997 Feb;145(2):479-83. doi: 10.1093/genetics/145.2.479.
A genotype probability index (GPI) is proposed to indicate the information content of genotype probabilities derived from a segregation analysis. Typically, some individuals are genotyped at a marker locus or a quantitative trait locus, and segregation analysis is used to make genotype inferences about ungenotyped relatives. Genotype probabilities for a two-allele autosomal locus are plotted on a triangular surface. The GPI has a value of zero at the point corresponding to Hardy-Weinberg frequencies, and a value of 100% at the vertices of the triangle. Trigonometric functions are used to help calculate intermediate index values. It is proposed that such an index can be useful to help identify which ungenotyped individuals or loci should be genotyped to maximize the benefit/cost of genotyping operations.
提出了一种基因型概率指数（GPI）来表示从分离分析得出的基因型概率的信息含量。通常，一些个体在标记位点或数量性状位点进行基因分型，然后使用分离分析对未进行基因分型的亲属进行基因型推断。双等位基因常染色体位点的基因型概率绘制在一个三角形平面上。GPI在对应于哈迪 - 温伯格频率的点处值为零，在三角形的顶点处值为100%。使用三角函数来帮助计算中间指数值。有人提出，这样一个指数有助于确定对哪些未进行基因分型的个体或位点进行基因分型，以使基因分型操作的效益/成本最大化。
