TRACE Wildlife Forensics Network, RZSS, Edinburgh, EH12 6LE, UK.
Forensic Sci Int Genet. 2012 Mar;6(2):e63-5. doi: 10.1016/j.fsigen.2011.04.015. Epub 2011 May 20.
Eighteen STR loci and one sex determination locus present in the Finnzymes Canine 2.1 STR Multiplex Reagent Kit were screened in the UK dog population providing allele frequencies and population genetic parameters necessary for the application of STRs to forensic genetic casework. A total of 375 dogs were genotyped, including representative samples from each of twelve breeds used to evaluate Hardy-Weinberg equilibrium and calculate inter-population pairwise F(ST) values. Three loci were excluded from calculations of average random match probability due to deviations from Hardy-Weinberg Equilibrium or ambiguous genotyping. Random match probability based on fifteen STR loci and one sex locus was subsequently estimated to be 2.8 × 10(-17) for unrelated individuals across breeds.
在英国犬群中筛选了 Finnzymes 犬 2.1 STR 多重扩增试剂盒中的 18 个 STR 基因座和 1 个性别决定基因座,提供了用于法医遗传学案件应用的 STR 等位基因频率和群体遗传参数。共对 375 只犬进行了基因分型,包括来自用于评估 Hardy-Weinberg 平衡和计算种群间成对 F(ST)值的 12 个品种的代表性样本。由于偏离 Hardy-Weinberg 平衡或基因分型不明确,有 3 个基因座被排除在平均随机匹配概率的计算之外。随后,基于 15 个 STR 基因座和 1 个性别基因座,对不同品种的无关个体的随机匹配概率估计为 2.8×10(-17)。