van der Reijden-Lakeman I E, de Sonneville L M, Swaab-Barneveld H J, Slijper F M, Verhulst F C
Department of Child and Adolescent Psychiatry, Sophia Children's Hospital/Erasmus University, Rotterdam, The Netherlands.
J Clin Exp Neuropsychol. 1997 Feb;19(1):101-18. doi: 10.1080/01688639708403840.
The objective of this study was to assess attention in children with short stature following intrauterine growth retardation (IUGR), at baseline and after 2 years of growth hormone (hGH) treatment. At baseline, all of the children had a birth height and a current height below the third centile. The attention measures (Sonneville Visual Attention Tasks: SVAT) of the IUGR group were compared with those of a comparison sample. In the baseline analyses, 48 children with IUGR and 119 comparison children were included; the 2-year follow-up analyses involved 41 children with IUGR and 68 comparison children. At baseline, children with IUGR showed deficits in divided, focused, and sustained attention. They were less accurate, exhibited more variability in reaction time, and performed more slowly and more impulsively than did the children in the comparison sample. After 2 years of hGH treatment, the IUGR group exhibited deficits in divided and sustained attention. They were still less accurate and showed more variability in reaction time and more impulsiveness. Current head circumference, the type of delivery, and global intelligence of children with IUGR were significantly correlated with attention measures. We hypothesize that short stature following IUGR and attention deficits are related, and that hGH treatment seems to have some beneficial effect on attentional capacity.
本研究的目的是评估宫内生长迟缓（IUGR）儿童在基线时以及生长激素（hGH）治疗2年后的注意力情况。在基线时，所有儿童的出生身高和当前身高均低于第三百分位数。将IUGR组的注意力测量指标（索内维尔视觉注意力任务：SVAT）与一个对照样本的指标进行比较。在基线分析中，纳入了48名IUGR儿童和119名对照儿童；2年随访分析涉及41名IUGR儿童和68名对照儿童。在基线时，IUGR儿童在分散注意力、集中注意力和持续注意力方面存在缺陷。与对照样本中的儿童相比，他们的准确性较低，反应时间的变异性更大，表现得更慢且更冲动。经过2年的hGH治疗后，IUGR组在分散注意力和持续注意力方面仍存在缺陷。他们的准确性仍然较低，反应时间的变异性更大，且更冲动。IUGR儿童当前的头围、分娩方式和整体智力与注意力测量指标显著相关。我们推测，IUGR后的身材矮小与注意力缺陷有关，并且hGH治疗似乎对注意力能力有一些有益影响。
