在人类胃溃疡模型中，碱性成纤维细胞生长因子促进愈合与消炎痛诱导的复发减少有关。
Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration.
作者信息
Hull M A, Knifton A, Filipowicz B, Brough J L, Vautier G, Hawkey C J
机构信息
Division of Gastroenterology, University Hospital, Queen's Medical Centre, Nottingham.
出版信息
Gut. 1997 Feb;40(2):204-10. doi: 10.1136/gut.40.2.204.
BACKGROUND
Acid stable basic fibroblast growth factor (bFGF) promotes angiogenesis and healing of gastric ulcers in rats and reduces subsequent non-steroidal anti-inflammatory drug (NSAID) induced relapse.
AIMS
To test in a double blind, placebo controlled, three way crossover study whether bFGF promotes healing and reduces subsequent relapse in a human model of gastric ulceration.
SUBJECTS
Twelve healthy volunteers.
METHODS
Subjects took aspirin 900 mg twice daily (days 1-3) with bFGF 0.1 mg twice daily or cimetidine 400 mg twice daily or placebo (days 1-14) and then indomethacin 50 mg thrice daily (days 15-21). Endoscopy was performed on days 1, 4, 8, 15, and 22 during each treatment period. Eight antral biopsy specimens were taken on day 1 and the number of unhealed biopsy induced mini-ulcers and NSAID induced erosions counted during subsequent endoscopies.
RESULTS
Basic FGF and cimetidine were protective against aspirin and indomethacin induced duodenal (but not gastric) injury compared with placebo. There was significant relapse of biopsy induced mini-ulcers after indomethacin only in the placebo group (0 (0-0) before v 1 (0-4.5) after; p > 0.05). TGP-580 was detected in serum of one volunteer.
CONCLUSIONS
Healing with bFGF (and cimetidine) was associated with reduced NSAID induced ulcer relapse in this model of gastric ulceration.
背景
酸稳定碱性成纤维细胞生长因子（bFGF）可促进大鼠胃溃疡的血管生成和愈合，并减少随后非甾体抗炎药（NSAID）诱导的复发。
目的
在一项双盲、安慰剂对照、三向交叉研究中，测试bFGF是否能促进人类胃溃疡模型的愈合并减少随后的复发。
研究对象
12名健康志愿者。
方法
受试者每天两次服用阿司匹林900毫克（第1 - 3天），同时每天两次服用bFGF 0.1毫克或每天两次服用西咪替丁400毫克或安慰剂（第1 - 14天），然后每天三次服用吲哚美辛50毫克（第15 - 21天）。在每个治疗期间的第1、4、8、15和22天进行内镜检查。在第1天采集8份胃窦活检标本，并在随后的内镜检查中计算未愈合的活检诱导微型溃疡和NSAID诱导糜烂的数量。
结果
与安慰剂相比，碱性成纤维细胞生长因子和西咪替丁对阿司匹林和吲哚美辛诱导的十二指肠（而非胃）损伤具有保护作用。仅在安慰剂组中，吲哚美辛治疗后活检诱导微型溃疡有显著复发（之前为0（0 - 0），之后为1（0 - 4.5）；p>0.05）。在一名志愿者的血清中检测到TGP - 580。
结论
在该胃溃疡模型中，bFGF（和西咪替丁）治疗与NSAID诱导的溃疡复发减少相关。
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