Römer W, Avril N, Dose J, Ziegler S, Kuhn W, Herz M, Jänicke F, Schwaiger M
Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München.
Rofo. 1997 Jan;166(1):62-8. doi: 10.1055/s-2007-1015379.
This study describes diagnostic accuracy of PET imaging in patients with ovarian tumours using histological diagnosis as gold standard.
Pet studies were performed in 19 patients who were scheduled to undergo exploratory surgery for a suspicious ovarian mass and in 5 patients with suspected recurrence. The PET data were analyzed visually and quantitatively and compared to the histologic findings. 6 patients had ovarian cancer, while in 13 patients a benign tumour was found including inflammatory processes in 4 cases. All malignant tumours showed an enhanced FDG uptake with the exception of one false-negative borderline carcinoma. 4 cases with inflammatory processes as well as endometrial and follicular cysts revealed a high FDG uptake. A successful localisation of a recurrent tumour was possible in 4 out of 5 cases. Disseminated peritoneal carcinomatosis in two patients could not be detected by PET.
Enhanced glucose metabolism of ovarian cancer enables PET diagnosis with a sensitivity of 83%. An intensive FDG uptake in inflammatory processes resulted in a specificity of only 54% in this study. The high sensitivity of PET for malignant tumours may be useful in the detection of recurrent ovarian cancer.
本研究以组织学诊断为金标准，描述正电子发射断层扫描（PET）成像在卵巢肿瘤患者中的诊断准确性。
对19例计划因可疑卵巢肿块接受 exploratory surgery（此处原文有误，推测为“探查性手术”）的患者以及5例疑似复发患者进行了PET研究。对PET数据进行了视觉和定量分析，并与组织学结果进行了比较。6例患者患有卵巢癌，13例患者发现为良性肿瘤，其中4例为炎症过程。除1例假阴性交界性癌外，所有恶性肿瘤均显示氟代脱氧葡萄糖（FDG）摄取增加。4例炎症过程以及子宫内膜和滤泡囊肿病例显示FDG摄取较高。5例中有4例成功定位了复发性肿瘤。PET未检测到2例患者的播散性腹膜癌。
卵巢癌增强的葡萄糖代谢使PET诊断的敏感性达到83%。在本研究中，炎症过程中强烈的FDG摄取导致特异性仅为54%。PET对恶性肿瘤的高敏感性可能有助于检测复发性卵巢癌。
