Sodja I, Mrázová M, Smelhausová M, Uhlír M, Kotrbová K, Pazdiora P, Bruj J, Kadlecík D
Státní zdravotní ústav, Praha.
Epidemiol Mikrobiol Imunol. 1996 Dec;45(4):143-7.
The human parvovirus B 19 was discovered in 1975 by Cossart but its etiological association with erythema infectiosum and hydrops of the foetus was proved only in 1984-1985. The objective of the submitted prospective study was to assemble basic findings on the herd immunity of the female population and the risk of infection with this agent during pregnancy. Seropositivity of women of fertile age before the epidemic of parvovirus B 19 in 1993 and 1994 was cca 50%, after the epidemic 70%. Erythema infectiosum is a childhood disease (96% of the cases are children under 14 years of age), but seroprevalence of parvovirus IgG in these age groups is only 11%. Thus the infection in adults is frequent but not diagnosed. A parvovirus etiology of possible loss of the foetus on the basis of serological examination is encountered only exceptionally. The Czech commercial preparation gammaglobulin can be used for prevention and treatment of a non-immune foetal hydrops.
人类细小病毒B19于1975年由科萨特发现，但直到1984 - 1985年才证实其与传染性红斑及胎儿水肿存在病因学关联。本前瞻性研究的目的是收集关于女性群体群体免疫力以及孕期感染该病原体风险的基础研究结果。1993年和1994年细小病毒B19流行前育龄女性的血清阳性率约为50%，流行后为70%。传染性红斑是一种儿童疾病（96%的病例为14岁以下儿童），但这些年龄组中细小病毒IgG的血清流行率仅为11%。因此，成人感染很常见但未被诊断出来。基于血清学检查，胎儿可能丢失的细小病毒病因仅在极少数情况下出现。捷克商业制剂丙种球蛋白可用于预防和治疗非免疫性胎儿水肿。
