Spustová V, Oksa A, Dzúrik R
Klinika farmakoterapie, Ustav preventívnej a klinickej medicíny, Bratislava.
Vnitr Lek. 1996 Dec;42(12):842-8.
The platelet growth factor (PDGF) is a potent proliferative factor which stimulates the proliferation of the kidneys in particular of mesangial cells and moreover by stimulating the production of the transforming growth factor beta (TGF-beta) it stimulates also proliferation of the mesangium, glomerulosclerosis and obviously also interstitial fibrosis. By these mechanisms it participates in the progression of experimental and human nephropathies. Production of PDGF can be suppressed by a low protein diet, heparin, acetylsalicylic acid, dipyridamol, and some new antagonists are being developed. These findings were assembled in experimental investigations and must be confirmed in clinical trials.
血小板生长因子（PDGF）是一种强效增殖因子，它能刺激肾脏尤其是系膜细胞的增殖，此外，通过刺激转化生长因子β（TGF-β）的产生，它还能刺激系膜增殖、肾小球硬化，显然也能刺激间质纤维化。通过这些机制，它参与了实验性和人类肾病的进展。低蛋白饮食、肝素、乙酰水杨酸、双嘧达莫可抑制PDGF的产生，并且一些新的拮抗剂正在研发中。这些发现是在实验研究中汇总的，必须在临床试验中得到证实。
