Wang J, Whetsell M, Klein J R
Department of Biological Science and Mervin Bovaird Center for Studies in Molecular Biology and Biotechnology, University of Tulsa, Tulsa, OK 74104, USA.
Science. 1997 Mar 28;275(5308):1937-9. doi: 10.1126/science.275.5308.1937.
Neuroendocrine hormones of the hypothalamus-pituitary-thyroid axis can exert positive or negative immunoregulatory effects on intestinal lymphocytes. Small intestine epithelial cells were found to express receptors for thyrotropin-releasing hormone (TRH) and to be a primary source of intestine-derived thyroid-stimulating hormone (TSH). The gene for the TSH receptor (TSH-R) was expressed in intestinal T cells but not in epithelial cells, which suggested a hormone-mediated link between lymphoid and nonhematopoietic components of the intestine. Because mice with congenitally mutant TSH-R (hyt/hyt mice) have a selectively impaired intestinal T cell repertoire, TSH may be a key immunoregulatory mediator in the intestine.
下丘脑-垂体-甲状腺轴的神经内分泌激素可对肠道淋巴细胞产生正向或负向免疫调节作用。研究发现，小肠上皮细胞表达促甲状腺激素释放激素（TRH）受体，并且是肠道源性促甲状腺激素（TSH）的主要来源。TSH受体（TSH-R）基因在肠道T细胞中表达，但在上皮细胞中不表达，这表明肠道的淋巴样和非造血成分之间存在激素介导的联系。由于先天性TSH-R突变的小鼠（hyt/hyt小鼠）肠道T细胞库存在选择性缺陷，TSH可能是肠道中关键的免疫调节介质。
