西索米星向庆大霉素C2b的生物转化。
Biotransformation of sisomicin to gentamicin C2b.
作者信息
Lee B K, Bailey J V, Condon R G, Marquez J A, Wagman G H, Weinstein M J
出版信息
Antimicrob Agents Chemother. 1977 Sep;12(3):335-8. doi: 10.1128/AAC.12.3.335.
Abstract
Sisomicin was transformed to gentamicin C(2b) by Micromonospora rhodorangea NRRL 5326. The mechanisms involved in the biotransformation are the 6'-N-methylation and the (4'-5')-reduction. The progression of the methylation was followed by the isotope technique, but the reduction reaction was not monitored.
摘要
西索米星被紫红小单孢菌NRRL 5326转化为庆大霉素C(2b)。生物转化涉及的机制是6'-N-甲基化和(4'-5')-还原。甲基化的进程通过同位素技术跟踪，但还原反应未进行监测。
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