Lashford L S
Ann Med. 1997 Feb;29(1):1-4. doi: 10.3109/07853899708998737.
Cancer is an acquired disease in which it is possible to identify a variety of abnormalities at a genetic level. This holds a promise that genetic manipulation of tumour cells will lead to novel therapies. As yet these approaches are constrained by available methods for obtaining gene transfer and subsequent genetic control. However, a number of strategies are already reaching the clinic, including attempts at immunotherapy, prodrug activation and improving host defence against conventional chemotherapy. Further clinical opportunities will occur with improved vector development.
癌症是一种后天性疾病，在基因层面有可能识别出多种异常情况。这意味着对肿瘤细胞进行基因操作有望带来新的治疗方法。然而，目前这些方法受到获取基因转移及后续基因控制的现有方法的限制。不过，一些策略已经进入临床阶段，包括免疫疗法、前药激活以及增强宿主对传统化疗的防御等尝试。随着载体开发的改进，还会出现更多的临床机会。
