Scott R E
Department of Pathology, University of Tennessee Medical Center, Memphis 38163, USA.
Pharmacol Ther. 1997;73(1):51-65. doi: 10.1016/s0163-7258(96)00120-9.
"Differentiation, Differentiation/Gene Therapy and Cancer" is intended to suggest that an understanding of the cell and molecular biology of cell differentiation should advance the development of new cancer therapies. This article, therefore, reviews four general topics and their relationship to each other: (1) the multistep process of cell differentiation in nontransformed and transformed cells, (2) the use of drugs that induce differentiation in vitro as potential clinical differentiation therapy agents for cancer, (3) the evolving emphasis on gene therapy as a new cancer therapy modality, and (4) the concept of differentiation/gene therapy.
《分化、分化/基因治疗与癌症》旨在表明，对细胞分化的细胞生物学和分子生物学的理解应能推动新型癌症治疗方法的发展。因此，本文回顾了四个一般主题及其相互关系：（1）未转化细胞和转化细胞中细胞分化的多步骤过程，（2）将体外诱导分化的药物用作癌症潜在临床分化治疗剂，（3）对作为一种新型癌症治疗方式的基因治疗的日益重视，以及（4）分化/基因治疗的概念。
