Herb A, Wisden W, Catania M V, Maréchal D, Dresse A, Seeburg P H
Department of Molecular Neurobiology, Max-Planck Institute for Medical Research and Laboratory for Molecular Neuroendocrinology, Heidelberg, Germany.
Mol Cell Neurosci. 1997;8(5):367-74. doi: 10.1006/mcne.1996.0594.
A recently cloned rat brain cDNA derives from a novel gene, termed dendrin (DEN), expressed exclusively in forebrain structures, particularly in neocortex, olfactory bulb, hippocampus, caudate-putamen, and limbic system. In these structures, the cognate mRNA is present in neuronal cell bodies and their dendrites, whereas near exclusive dendritic localization is observed for the polypeptide product. In the hippocamus, DEN mRNA is highly expressed in the cell laminae and dendritic layers of the dentate gyrus and CA1 field, but expression is markedly reduced in the CA3 and CA4 areas. The predicted primary structure of the hydrophilic, highly basic 653-amino-acid polypeptide does not suggest a function. The restricted expression and dendritic location are compatible with a role for DEN in synaptic plasticity of central neocortical forebrain neurons.
最近克隆的大鼠脑cDNA源自一个新基因，称为树突蛋白（DEN），仅在前脑结构中表达，特别是在新皮层、嗅球、海马体、尾状核-壳核和边缘系统。在这些结构中，相关mRNA存在于神经元细胞体及其树突中，而多肽产物几乎只定位于树突。在海马体中，DEN mRNA在齿状回和CA1区的细胞层和树突层中高度表达，但在CA3和CA4区表达明显降低。预测的由653个氨基酸组成的亲水性、高碱性多肽的一级结构并未提示其功能。其有限的表达和树突定位表明DEN在中枢新皮层前脑神经元的突触可塑性中发挥作用。
